Wegener syndrome (wegener granulomatosis) 1

General: Etiology unknown; occurs in fourth and fifth decades of life; pe 232i87c rsistent rhinitis or sinusitis; three characteristic features are necrotizing granulomatous lesions in the respiratory tract, generalized focal arthritis, and necrotizing thrombotic glomerulitis,

Ocular: Exophthalmos; lid and conjunctival chemosis; papillitis; conjunctivitis; corneal ulcer; corneal abscess; optic atrophy; optic neuritis; orbital cellulitis; episcleritis; sclerokeratitis; cataract; peripheral ring corneal ulcers; ptosis; dacryocystitis; retinal periphlebitis; cotton-wool spots; retinal and vitreous hemorrhages; rubeosis iridis; neovascular glaucoma.

Clinical: Severe sinusitis; pulmonary inflammation; arteritis; weakness; fever; weight loss; bony destruction; granulomatous vasculitis of the upper and lower respiratory tracts; glomerulonephritis; diffuse pulmonary infiltrates; lymphadenopathy; diffuse pulmonary hemorrhage; overlap with giant cell arteritis.

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