Weber-christian syndrome (pfeiffer-weber-christian syndrome) 1

General: Etiology unknown; subcutaneous inflammatory lesions; occurs at any age; no g 111i84b ender dominance.

Ocular: Secondary glaucoma; anterior uveitis; acute exudative central choroiditis.

Clinical: Generalized distribution of subcutaneous nodular lesions that vary in size and are located predominantly on the trunk, arms, and legs; recurrent attacks of fever; anorexia; hepatosplenomegaly; malaise; oropharyngeal infections; myocardosis; liver cirrhosis; retroperitoneal fibrosis; ulcerative colitis; myalgia; cardiac dilatation with congestive heart failure.

Christian HA. Relapsing febrile nodular non-suppurative panniculitis. Arch Intern Med 1928; 42:338.

Lemley DE, et al. Cardiac manifestation of Weber-Christian disease: report and review of the literature. J Rheumatal 1991; 18:756-760.

Nozue M, et al. Ulcerative colitis associated with Weber-Christian panniculitis and musculitis: a case report. J Gastroenterol 1994; 29:84-87.

Ohara S, et al. Myalgia as the major symptom in systemic panniculitis (Weber-Christian disease). Eur Neurol 1992; 32:321-323.

Popoff N, Weelock M. Relapsing febrile nodular nonsuppurative panniculitis. Pfeiffer- Weber-Christian disease: report of three cases. Arch Intern Med 1956; 97:39.

Weber FP. A case of relapsing non-suppurative nodular panniculitis, showing phagocytosis of subcutaneous fat cells by macrophages. Br J Dermatol Syphil 1925; 37:301.