Stevens-johnson syndrome (dermatostomatitis; erythema multiforme exudativum; syndroma mucocutaneo-oculare; baader dermatostomatitis syndrome; mucosal-respiratory syndrome; fuchs [2] syndrome; mucocutaneous ocular syndrome)

General: Etiology unknown; affects all ages; most frequently seen in first and third decades of life; prevalent in males; drugs are the most commonly identified etiologic factor in this condition.

Ocular: Hypopyon; iritis; keratitis; corneal ulcers; keratoconjunctivitis sicca; chemosis; conjunctivitis; widespread fibrinoid necrosis of conjunctival vessels; blepharitis; endophthalmitis; phthisis bulbi; uveitis; cataracts; pannus; optic neuritis; keratoconus; adenoviral conjunctivitis has been reported to have precipitated Stevens-Johnson syndrome; orbital cyst may be a complication.

Clinical: General malaise, headaches, chills, and fever; severe skin and mucous membrane eruptions (erythema multiforme); dorsa of hands and feet are most frequently affected; rhinitis; balanitis; vulvovaginitis; urethritis (nonspecific); cystitis; patients with AIDS are at higher risk of developing Stevens-Johnson syndrome.

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Kaido M, Goto E, Dogru M, et al. Punctal occlusion in the management of chronic Stevens-Johnson syndrome. Ophthalmology 2004; 111: 895-900.

Power WJ, et al. Analysis of the acute ophthalmic manifestations of the erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrolysis disease spectrum. Ophthalmology 1995; 102:1669-l676.

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