Multiple mucosal neuromata with endocrine tumors syndrome (multiple mucosal neuromas, pheochromocytoma, and medullary thyroid carcinoma syndrome)

General: Pheochromocytoma can be inherited and found in combination with neurofibromatosis and other brain tumors (meningioma, spongioblastoma, ependymoma, astrocytoma, cerebellar hemangioblastoma), multiple mucosal neuromas, and medullary carcinoma of the thyroid.

Ocular: Conjunctival neuromas; multiple, white, myelinated nerve fibers in corneal stroma arising at limbus with anastomoses in center of cornea.

Clinical: Neuromas of lips or anterior portion of tongue or, more rarely, of buccal, gingival, or laryngeal mucosa; hypertension; flushing; weakness; sweating; palpitations; headaches.

Burgdorf W. Letter: multiple mucosal neuroma syndrome. Arch Dermatol 1975; 111:931.

Paloyan E, et al. familial pheochromocytoma, medullary thyroid carcinoma and parathyroid adenomas. JAMA 1970; 214:1443.

Williams ED, Pollock DJ. Multiple mucosal neuromata with endocrine tumors: a syndrome allied to von Recklinghausen's disease. J Pathol Bacteriol 1966; 91:71.