Mbius i syndrome (hemicrania, hemiplegic; hemiplegic-ophthalmoplegic migraine; hemiplegic familial migraine)

General: Etiology unknown; indirect indications of unilateral cerebral edema due to vasomotor phenomena; occurs in young adults; recovery usually follows after a few days; no clear etiology has been determined, including a vascular theory of embryopathogene-sis, a chromosome translocation, and exposure to teratogens.

Ocular: Extraocular palsy; permanent damage of oculomotor nerve III.

Clinical: Hemicrania; hemiparesis; aneurysm of internal carotid; neoplasia; headache.

D'Cruz OF, et al. Mobius syndrome: evidence for a vascular etiology. J Child Neurol 1993; 8:260-265.

Donahue SP, et al. Broad-spectrum Mobius syndrome associated with a I; II chromosome translocation. Ophthalmic Paediatr Genet 1993; 14:17-21.

Kankirawatana P, et al. Mobius syndrome in infant exposed to cocaine in utero. Pediatr Neurol 1993; 9:71-72.

Lipson T, et al. The Mobius syndrome: etiology, incidence of mental retardation and genetics [Letter]. J Med Genet 1990; 27:533-535.

Magalini SI, Scrascia E. Dictionary of Medical Syndromes, 2nd ed. Philadelphia: JB Lippincott, 1981.

McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders, 12^th ed. Baltimore: The Johns Hopkins University Press, 1998.

Online Mendelian Inheritance in Man, OMIM. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University and National Center for Biotechnology Information, National Library of Medicine, February 12, 2007. World Wide Web URL: https://www.ncbi.nlm.nih.gov/omim/.

Mobius PJ. Ueber Periodishe Wiederkehrende Oculomotoriuslachennung. Klin Wochenschr