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Herrick syndrome (dresbach syndrome; sickle cell disease; drepanocytic anemia) 5


Herrick Syndrome (Dresbach Syndrome; Sickle Cell Disease; Drepanocytic Anemia) 5

General: Usually occurs in members of the black race; poor prognosis.

Ocular: Secondary glaucoma; telangiectasis of conju 747f55h nctival vessels; scleral icterus; vitreous hemorrhages; cataract; retinal hemorrhages, exudates, and neovascularization; retinitis proliferans; microaneurysms; thrombosis of retinal venules; retinal vascular sheathing; central vein occlusion; angioid streaks; retinopathy with 'black sunburst sign' in patients with SS hemoglobin; 'sea fan sign' in patients with SC hemoglobin; comma signs of conjunctiva; fan-shaped neovascularization of iris; sector ischemic atrophy of iris; optic atrophy; white cotton mass of vitreous; retinal holes; color vision defects; central retinal artery obstruction; branch retinal artery obstruction; white without pressure; venous tortuosity; sickling maculopathy.

Clinical: Severe anemia with hemolytic crises; bone and joint aches; hemarthrosis; jaundice; hepatosplenomegaly.



Asdourian GK. Sickle cell retinopathy. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. II. Philadelphia: WB Saunders, 1994.

Fraunfelder FT, Roy FH. Current Ocular Therapy, 5th ed. Philadelphia: WB Saunders, 2000.

Goldberg MF. The diagnosis and treatment of secondary glaucoma after hyphema in sickle cell patients. Am J Ophthalmol 1979; 87:43-49.

Majekodunmi SI, Akinyanju OO. Ocular findings in homozygous sickle cell disease in Nigeria. Can J Ophthalmol 1978; 13:160-l62.

Nagpal KC, et al. Ocular manifestations of sickle hemoglobinopathies. Surv Ophthalmol 1977; 21:391-411.

Roy MS, et al. Color vision defects in sickle cell anemia. Arch Ophthalmol 1987; 105:1676-l678.

Vogel M. Sickle-cell disease: a clinicopathologic case report. Ophthalmologica 1977; 175:171-l74, 1977.

Westrich DJ, Feman SS. Macular arteriolar occlusions in sickle cell beta-thalassemia. Am J Ophthalmol 1986; 101: 739-740.




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