Hemochromatosis

General: Iron metabolism disorder; genetically determine 737g66h d, but mode of inheritance unknown; male preponderance 10:1; inheritance is autosomal recessive.

Ocular: Eyelid hyperpigmentation; diabetic retinopathy.

Clinical: Hemosiderin pigment deposition in many tissues; diabetes mellitus; cutaneous hyperpigmentation; cirrhosis of the liver; hypermelanotic pigmentation of skin; heart failure.

Boreck IB, et al. Combined segregation and linkage analysis of genetic hemochromatosis using affection status, serum iron and HLA. Am J Hum Genet 1990; 47Z:542-550.

Collins JF. Handbook of Clinical Ophthalmology. New York: Masson, 1982.

Davies G, et al. Deposition of melanin and iron in ocular structures in haemochromatosis. Dr J Ophthalmol 1872; 56: 338.