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Eaton-lambert syndrome (myasthenic syndrome; ocular myoclonus syndrome; myoclonic syndrome)  396


Eaton-Lambert Syndrome (Myasthenic Syndrome; Ocular Myoclonus Syndrome; Myoclonic
Syndrome) 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d 343b14d   396

General: Males; over 40 years of age; intrathoracic tumor; myasthenia-like condition less likely to have ocular manifestations; positive association with small cell cancer of the lung; underlying autoimmune basis.

Ocular: Decreased amplitude of version in all directions of gaze; ocular myoclonus; corneal abrasion; decreased corneal sensitivity; conjunctival injection; miotic pupil.

Clinical: Weakness; fatigue; peripheral paresthesia; dryness of mouth.

Cogan D. Myasthenia gravis. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. V. Philadelphia: WB Saunders, 1994:2489.

Eaton LM, Lambert EM. Electromyography and electric stimulation of nerves in diseases of the motor units; observations on myasthenic syndrome associated with malignant tumors. J Am Med Assoc 1957; 163:1117.

Fetell MR, Younger DS. Neurologic paraneoplastic syndromes. In: Rowland LP, ed. Merritt’s Textbook of Neurology, 9th ed. Baltimore: Williams & Wilkins, 1995:935-936.

Geeraets WJ. Ocular Syndromes, 3rd ed. Philadelphia: Lea & Febiger, 1976.

Penn AS. Lambert-Eaton syndrome. In: Rowland LP, ed. Merritt’s Textbook of Neurology. 9th ed. Baltimore: Williams & Wilkins, 1995:761-763.

Sanders DB, Howard JF. Disorders of neuromuscular transmission. In: Bradley WG, et al. Neurology in Clinical practice. 2nd ed. Boston: Butterworth-Heinemann, 1995:1998-l999.




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