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Chronic granulomatous disease of childhood  249


Chronic Granulomatous Disease of Childhood   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;   &nb 525h74f sp;  249

General: Genetically determined metabolic defect manifested by inability of the leukocytes to operate the hexose monophosphate shunt during phagocytosis.



Ocular: Conjunctivitis; keratitis; destructive chorioretinal lesions.

Clinical: Eczematous dermatitis; microabscesses of the skin, lymph nodes, and viscera.

Andersen SR. Vascular lesion (arteriovenous aneurysm or haemangioma) of the orbit in a case of chronic granulomatous disease. Ophthalmologica 1976; 173:145-l5l.

Harley RD, ed. Pediatric Ophthalmology. 4th ed. Philadelphia: WB Saunders, 1998.

Lischner HW, Martyn LJ. Chorioretinal lesions, sea-blue histiocytes and other manifestations in familial chronic granulomatous disease. Birth Defects 1975; 11:73-76.




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