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Bing-neel syndrome  147


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General: Association of macroglobulinemia and central nervous system symptoms; excessive production of gamma M globulin; over 50 years of age; anoxia secondary to blood sludging from increased viscosity is exation for peripheral retinal vascular changes.

Ocular: Ptosis; paralysis of extraocular muscles; glaucoma; chorioretinitis; dilated and segmented retinal veins; vascular tortuosity; retinal hemorrhages; peripheral microaneurysms; mild papilledema.

Clinical: Chronic encephalopathy; peripheral neuropathy; strokes; subarachnoidal hemorrhages; weakness; fatigability; weight loss; splenomegaly; anemia.

Bing J, Neel AV. Two cases of hyperglobulinemia with affection of central nervous system on a toxi-infectious basis. Acta Med Scand 1936; 88:492.

Frase DM, et al. Mononeuritis multiplex in a patient with macroglobulinemia. J Neurol Neurosurg Psychiatry 1976; 39:711-715.

Imai F, et al. Intracerebral infiltration by monoclonal plasmacytoid cells in Waldenstrom's macroglobulinemia. Case report. Neurol Med Chir (Tokyo) 1995; 35:575-579.

Magalini SI, Scrascia E. Dictionary of Medical Syndromes. 2nd ed. Philadelphia: JB Lippincott, 1981.

Miller NR. Walsh and Hoyt's Clinical Neuro-Ophthalmology. vol. 2, 4th ed. Baltimore: Williams & Wilkins, 1987.




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