Amendola syndrome

General: Observed in Sao Paulo, Brazil; all ethnic groups are affected; endemic form of pemphigus foliaceus; possibly caused by environmental agents; autoimmune disease mediated by autoantibodies of the immunoglobulin G (IgG) class, IgG4 subclass.

Ocular: Blisters around eyebrows; entropion; ectropion; trichiasis; iritis.

Clinical: Brazilian pemphigus (fogo selvagem, 'wild fire'), which resembles, because of its appearance, pemphigus foliaceus; fever; chills.

Amendola F. Cataracta No Pemo Foliaceo (nota previa). Rev Paul Med

Korting GW. The skin and the eye: a dermatologic correlation of diseases of the periorbital region. Philadelphia: WB Saunders, 1973:82.

Magalini SI, Scrascia, E. Dictionary of Medical Syndromes, 2nd ed. Philadelphia: JB Lippincott, 1981.

Sampaio SA, et al. Brazilian pemphigus foliaceus, endemic pemphigus foliaceus or fogo selvagem (wild fire). Dermatol Clin 1994; 12:765-776.