Hallermann-streiff syndrome (dyscephalic-mandibulo-oculo-facial syndrome; oculo-mandibulo-dyscephaly; ullrich-fremery-dohna syndrome; francois dyscephalic syndrome; mandibulo-oculo- facial dyscephaly syndrome; francois-hallermann-streiff syndrome; hallermann-streiff-francois syndrome; audry i syndrome; dohna syndrome; francois syndrome (1); dyscephaly- teeth abnormality-dwarfism; dyscephalia oculomandibularis-hypotrichosis; mandibulo-ocular dyscephalia hypotrichosis; fremery-dohna syndrome; oculo-mandibulo-facial dyscephaly)

General: Rare; familial occurrence and consanguinity; males and females equally affected.

Ocular: Microphthalmos (bilateral); proptosis; nystagmus; strabismus; cataracts; bilateral optic atrophy; coloboma of optic disk, choroid, and iris; keratoglobus; microcornea; antimongoloid slant; iris atrophy; uveitis; blue sclera; persistent pupillary membrane; secondary glaucoma.

Clinical: Malformations of skull (brachycephaly), facial skeleton, and jaws; erupted teeth at birth; diminished hair growth; hyperextensibility of joints; short stature; skin atrophy; mental deficiency; predisposition to upper airway compromise; obstructive sleep apnea.

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Ronen S, et al. The early management of baby with Hallermann-Streiff-Francois syndrome. J Pediatr Ophthalmol Strabismus 1979; 16:119-l21.

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