General: Widespread cortical atrophy; manifested bet 333g61d ween 40 and 70 years; pathogenesis remains unknown; cannot be consistently differentiated from Alzheimer disease on clinical grounds alone.
Ocular: Apperceptive blindness (inability of patient to fix upon objects within his or her gaze); visual agnosia (inability to recognize familiar objects by sight); visual field defects due to atrophy in occipital lobe.
Clinical: Presenile or progressive dementia; patient is unaware of his or her surroundings; poor insight; loss of words and utterance of stereotyped phrases; aphasia (motor type); apathy and indifference.
Magalini SI, Scrasia E. Dictionary
of Medical Syndromes, 2nd ed.
Morris JC, et al. Hereditary dysphasic dementia and the Pick-Alzheimer spectrum. Ann Neurol 1984; 16:455-466.
Pick A. Apperzeptive Blindheit der Senilen. Arb Dtsch Psychiatr Klin Prag 1908:43.
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