Acanthosis nigricans

General: Rare skin disease of unknown etiology; occurs at any age; equal frequency in males and females; thickening and hyperpigmentation of the skin of the entire body, especially in flexural areas; autosomal dominant inheritance.

Ocular: Conjunctivitis; pigmentation of palpebral conjunctiva; tumors on lids and lid margins; madarosis; trichiasis.

Clinical: Hyperkeratotic lesions on face, neck, oral mucosa, axillae, groin, antecubital fossae, and umbilicus.

Fraunfelder FT, Roy FH. Current Ocular Therapy, 5th ed. Philadelphia: WB Saunders, 2000.

Lamba P, Lal S. Ocular changes in benign acanthosis nigricans. Dermatologica 1970; 140:356.

McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders, 12th ed. Baltimore: The Johns Hopkins University Press, 1998.

Online Mendelian Inheritance in Man, OMIM. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University and National Center for Biotechnology Information, National Library of Medicine, February 12, 2007. World Wide Web URL: https://www.ncbi.nlm.nih.gov/omim/.

Tasjian D, et al. Familial acanthosis nigricans. Arch Dermatol 1984; 120:1351-l354.

Whitmore PV. Skin and mucous membrane disorders. In: Duane TD, ed. Clinical Ophthalmology, vol. V. Philadelphia: JB Lippincott, 1982:9-l0.