Rhabdomyosarcoma
General: Most common malignant orbital neoplasm of childhood; usual 949g64j ly occurs before age 10 years; more commonly seen in males; rarely may develop in adults; shows evidence of striated muscle differentiation; has been divided into three histopathologic types: embryonal, alveolar, and pleomorphic.
Ocular: Choroidal folds; corneal edema; exposure keratitis; rhabdomyosarcoma of orbit or extraocular muscles; decreased motility; proptosis; papilledema; orbital edema; enlarged optic foramen; erosion of bony walls of orbit; pupil irregularity; epiphora; glaucoma; visual loss; nasolacrimal duct obstruction; conjunctival mass.
Clinical: Metastasis to the lymph system, bone marrow, and lungs; headaches.
Abramson DH, et al. The treatment of orbital rhabdomyosarcoma with irradiation and chemotherapy. Ophthalmology 1979; 86:1330-l335.
Baron EM, et al. Rhabdomyosarcoma manifesting as acquired nasolacrimal duct obstruction. Am J Ophthalmol 1993; 115:239-242.
Fraunfelder FT, Roy FH. Current Ocular Therapy, 4th ed. Philadelphia: WB Saunders, 2000.
Knowles DM II, et al. Ophthalmic striated muscle neoplasms. Surv Ophthalmol 1976; 21:219-261.
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