Gradenigro Syndrome (Temporal Syndrome; Lannois-Gradenigro Syndrome)
General: Caused by extradural abscess of the petrous portion of the temporal bone; good prognosis.
Ocular: Ipsilateral paralysis (cranial nerve VI); transient involvement of cranial nerves III and IV occasionally present; severe pain in area of ophthalmic branch (cranial nerve V); photophobia; lacrimation; reduced corneal sensitivity; optic nerve involvement occasionally present.
Clinical: Inner ear infection with deafness; mastoiditis; facial paresis possible; temperature may be elevated; meningeal signs possible; can occur rarely as a complication of otitis media.
De Graaf J, et al. Gradenigo's syndrome: a rare complication of otitis media. Clin Neural Neurosurg 1988; 90:237.
Gradenigro G. A special syndrome of endocranial otitic complications. Ann Otol Rhinol Laryngol 1904; 13:637.
Joffe WS. Clinical nerve disease. Int Ophthalmol Clin 1967; 7:823.
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