Cushing (1) syndrome (adrenocortical syndrome; hyperadrenalism syndrome; pituitary basophilism; suprarenal syndrome)  335

General: Excessive secretion of adrenal cortical hormones due to primary or secondary adrenal hyperplasia or induced by adrenal or extraadrenal neoplastic tissue; common in females of childbearing age.

Ocular: Proptosis (rare); ocular muscle palsies; uncharacteristic visual field changes (not necessarily resembling bitemporal hemianopsia); optic nerve and/or chiasmal compression either unilateral or bilateral; posterior subcapsular cataract; central serous retinopathy; Lisch nodules.

Clinical: Hirsutism; obesity; 'buffalo hump'; hypertension; diabetes; skin pigmentation; osteoporosis; abdominal striae; polycythemia and lymphopenia; weakness; nervousness; irritability; dysmenorrhea.

Bouzas EA, et al. Central serous chorioretinopathy in endogenous hypercortisolism. Arch Ophthalmol 1993; 111: 1229-l233.

Bouzas EA, et al. Lisch nodules in Cushing's disease. Arch Ophthalmol 1993; 111:439-440.

Bouzas EA. et al. Posterior subcapsular cataract in endogenous Cushing syndrome: an uncommon manifestation. Invest Ophthalmol Vis Sci 1993; 34:3497-3500.

Cushing H. The basophil adenomas of the pituitary body and their Clinical manifestations (pituitary basophilism). Bull Johns Hopkins Hosp 1932; 50: 137.

Rovit RL, Duane TD. Eye signs in patients with Cushing's syndrome and pituitary tumors: some observations related to chromophobe tumors and hyperadrenalism. Trans Am Ophthalmol Soc 1967; 65:52.